Bioidentical hormone is a hormone that has an identical molecular structure to a human hormone, the same one that your body makes. They are natural hormones in contrast to synthetic hormones or those derived from animals (pregant horse's urine). This means that the biological functions and effects of bioidentical hormones are more natural to your body. Bioidentical hormones are derived from plant sterols of either soy or yam origin.However, bioidentical hormones are not phytohormones.
Rather, human hormones (bioidentical hormones) are synthesized from these plant steroids through very complex chemical processes. The demand for bioidentical hormones grew in response to the results published by Women’s Health Initiative (WHI) in the early 1990s which linked six deadly risks in women to the use of synthetic hormones. WHI is the largest U.S. prevention studies of its kind that spanned over 15 years and  enrolled more  than 160,000 postmenopausal women aged 50-79. The study looked at the use of conjugated estrogen(Premarin), made from horse urine versus Premarin plus medroxyprogesterone (Prempro). The risk of synthetic hormones has also been demonstrated in men. The “Coronary Drug Project” showed an excess of deaths resulting from stroke and heart attack was linked to the use of conjugated estrogens (synthetic estrogens).
Medroxyprogesterone is a synthetic progesterone known as a progestin. Progestins must be distinguished from natural progesterone. To illustrate their differences, progestins are used in birth control pills, whereas natural progesterone is used during pregnancy to prevent mischariage. Just a fraction of progestin dose during pregnancy may cause birth defects. Clearly, progestins are not progesterone. Progestins mimic the functions of progesterone by binding with progesterone receptors to oppose estrogen. However, the benefits of progestins also come with the cost of their unnatural effects on the body, intefering with the liver and its functions. But the The key to hormone balance is to achieve a balance of progesterone and estradiol. It is important to mention that unopposed estrogen is a known risk in hormone therapy, including bioidentical hormone therapy (BHRT). And there are factors that contribute to that risk such as genetics, liver health, hormone ridden diet, environmental toxins (xenoestrogens, BPA), build up of endogenous estrogens and the body's inability to effectively elimiate them.

  • Bioidentical estrogens are- Estrone (E1), Estradiol (E2), Estriol (E3)
  • Bioidentical progesterone is simply called progesterone.
  • Bioidentical testosterone is simply called testosterone.
  • Examples of synthetic estrogens- ethinylestradiol, estradiol valerate
  • Examples of synthetic progesterone- norethindrone, levonorgesterol, drospirenone, medroxyprogesterone acetate
  • Examples of synthetic testosterone- testosterone cypionate, methyltestosterone

Wells Pharmacy offers BHRT formulations for men that address the challenges of aromatization. Formulations containing estrogen blockers such as progesterone, chrysin or anastrazole (aromatase inhibitor) are available in custom dosages and combinations with testosterone and DHEA.

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